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Developing an oral GLP-1 pill has been challenging because these peptide-based drugs are easily broken down in the stomach
10.1038/s41467-019-12934-8 Nat
These cardiovascular characterisation studies established that MT-IIs haemodynamic effects are mechanistically related to its central MC3R/MC4R activation rather than to peripheral melanocortin receptor engagement
Lyophilised powder, dual-compound
But risk of unknown long-term effects, risk of interactions with medications we haven't tested, risk of immune sensitization after repeated dosing, and risk of phosphate imbalances in individuals with compromised renal function
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